Chuchu WANG | Wang Lab

NTU AI-for-X Postdoctoral Fellowship Opportunity in Wang Lab

Tue, 08 Sep 2026 00:00:00 +0000

We are looking for early-career researchers interested in applying for the NTU AI-for-X Postdoctoral Fellowship to develop AI-driven methods for cryo-EM/ET, automated data analysis, and the structural study of native neuronal systems.

The Wang Lab at Nanyang Technological University (NTU), Singapore welcomes outstanding postdoctoral fellowship candidates who are excited to work at the interface of artificial intelligence, structural biology, neuroscience, and neurodegeneration research.

Fellowship

The NTU AI-for-X Postdoctoral Fellowship supports promising early-career researchers who aim to develop AI methods for challenging scientific problems. The 2026 application deadline is 30 October 2026, 23:59 Singapore time. Applicants should review the official fellowship requirements and application timeline on the NTU AI-for-X Postdoctoral Fellowship page.

Research Direction

The fellow will work with Dr. Chuchu Wang to develop and apply AI-driven approaches for:

Automated analysis of cryo-electron tomography and cryo-electron microscopy data
Structural studies of native neuronal and synaptic systems
In situ analysis of protein-lipid interactions in aging and neurodegenerative disease
Data integration across cryo-EM/ET, cell biology, and mass spectrometry-based multi-omics
Cryo-FIB milling workflows using Aqilos for native cellular sample preparation

Candidate Profile

We welcome applicants with a PhD in a STEM discipline, especially those with experience or strong interest in one or more of the following areas:

Artificial intelligence, machine learning, computer vision, or image analysis
Cryo-EM, cryo-ET, structural biology, biophysics, or cell biology
Neuroscience, neurodegeneration, membrane biology, or synaptic biology
Scientific programming and reproducible computational workflows

Candidates should be motivated to build independent research directions, work collaboratively across disciplines, and contribute to a supportive lab environment.

How to Apply

Interested candidates are encouraged to contact Dr. Chuchu Wang before submitting the official fellowship application. Please send the following materials to chuchu.wang@ntu.edu.sg:

CV
A brief description of your research interests and fit with the Wang Lab
Contact information for 2-3 referees

Please use the email subject line:

NTU AI-for-X Postdoctoral Fellowship - Your Name

Recent Structural Insights into the Molecular Architecture of Synapses

Fri, 23 Jan 2026 00:00:00 +0000

Opportunities in Wang Lab

Wed, 14 May 2025 00:00:00 +0000

Job Opportunities in Wang Lab at Nanyang Technological University (NTU), Singapore

Institution Overview

Nanyang Technological University (NTU), Singapore, is a world-renowned research-intensive university, ranked 15th globally in the 2025 QS World University Rankings. NTU is recognized for its academic excellence, groundbreaking research, and global outlook. The university offers a vibrant, interdisciplinary research environment with state-of-the-art facilities and comprehensive support services.

About the Lab

Dr. Chuchu Wang will join NTU’s Lee Kong Chian School of Medicine (LKCMedicine) as an Assistant Professor in November 2025 and has been awarded the prestigious Nanyang Assistant Professorship (NAP) grant. The lab will be well-funded and housed in a dynamic and collaborative research environment.

Dr. Wang received her Ph.D. in Cell Biology in 2019 under the supervision of Dr. Cong Liu at the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences. From 2020 to 2025, she conducted postdoctoral research at Stanford University under the guidance of HHMI Investigator Prof. Axel Brunger, focusing on structural and molecular neuroscience. Dr. Wang has published as first or co-first author in journals including Nature, Nature Aging, Nature Cell Biology, Nature Communications, Nature Protocols, National Science Review, PNAS, eLife, and Bioinformatics.

Google Scholar: https://scholar.google.co.uk/citations?hl=en&user=1SQy-gQAAAAJ

Research Focus

Our interdisciplinary lab combines in situ structural biology (cryo-EM/ET, in-cell NMR), mass spectrometry-based lipidomics and proteomics, cell biology, bioinformatics, and molecular biology to investigate the physiological and pathological mechanisms of human aging and neurodegenerative diseases.

The lab aims to integrate multi-omics, molecular structural analysis, and biochemical/cellular experiments to uncover lipid–protein interactions in age-related disorders, with the ultimate goal of identifying early diagnostic markers and therapeutic strategies to promote healthy aging.

We welcome applicants from diverse backgrounds (e.g., neuroscience, biophysics, biochemistry, bioinformatics), who are passionate about impactful, translational research.

Collaborations

Our lab maintains active collaborations with leading institutions in the US, Singapore, and China, offering lab members the opportunity to engage with top-tier researchers globally.

Open Positions

1. PhD Students & Undergraduate Researchers

We are recruiting PhD students for January 2026 intake (application period: May 1 – June 30, 2025). August intake applications open September 1 – December 31 annually.

Benefits:

Full scholarship and competitive monthly stipend
Support for international conference travel (funded by both the school and the lab)
Access to cutting-edge facilities and mentorship in a collaborative research environment

Eligibility:

English proficiency: TOEFL ≥ 100 or IELTS ≥ 6.5 (within 2 years); required unless graduated from English-medium institutions
GRE required for non-Singapore degree holders (V+Q ≥ 319; AW ≥ 3.5, within 5 years)

Application info: NTU LKCMedicine PhD Admissions

Outstanding undergraduates are also encouraged to join for research training and thesis projects.

2. Postdoctoral Research Fellow

Qualifications:

Ph.D. in biology, neuroscience, biophysics, structural biology, bioinformatics, or related fields
Experience in neurocell biology, cryo-EM/NMR, or omics data analysis preferred
Proven ability to conduct independent research
Strong publication record (first-author papers or preprints)
Excellent communication and teamwork skills
Ability to mentor students and contribute to grant writing

Compensation:

Competitive salary based on experience and NTU guidelines
Support for fellowship applications and career development
Funding for conferences and collaborative visits

3. Research Assistant

Qualifications:

Bachelor’s degree or above
Prior experience in protein purification, cell culture, or animal handling is a plus
Familiarity with EM/NMR data or omics analysis is desirable
Ability to work independently and collaboratively
Fluent in written and spoken English

Compensation:

Salary will be competitive and commensurate with experience
Opportunities to co-author publications and attend international meetings

4. Visiting Scholars & Joint PhD Students

We welcome visiting researchers and joint PhD students interested in collaborative or short-term research exchanges.

Application Instructions

To apply, please send the following documents in English to chuchu.wang@ntu.edu.sg:

Cover letter (briefly describing your past experience and research interests)
CV
Contact details of 2–3 referees

Email subject format: [Application Position] - [Your Name], e.g., Postdoc Application – David Liu, PhD Application – Jeremy Lee

Applicants will be contacted for interviews shortly after submission.

N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

Fri, 27 Dec 2024 00:00:00 +0000

In-Situ Structure and Topography of AMPA Receptor Scaffolding Complexes Visualized by CryoET

Sun, 20 Oct 2024 00:00:00 +0000

Nonlinear dynamics of multi-omics profiles during human aging

Wed, 14 Aug 2024 00:00:00 +0000

Observing isolated synaptic vesicle association and fusion ex vivo

Tue, 02 Jul 2024 00:00:00 +0000

VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates

Mon, 01 Jul 2024 00:00:00 +0000

Paper accepted in Nature

Wed, 05 Jun 2024 00:00:00 +0000

Our paper Structure and topography of the synaptic V-ATPase–synaptophysin complex has been accepted for publication in Cell Host & Microbe.

Paper Link

Structure and topography of the synaptic V-ATPase–synaptophysin complex

Wed, 05 Jun 2024 00:00:00 +0000

Lysophosphatidylcholine binds α-synuclein and prevents its pathological aggregation

Sat, 01 Jun 2024 00:00:00 +0000

Beyond the MUN domain Munc13 controls priming and depriming of synaptic vesicles

Mon, 20 May 2024 00:00:00 +0000

A new method for isolation and purification of fusion-competent inhibitory synaptic vesicles

Thu, 28 Mar 2024 00:00:00 +0000

Multi-omics microsampling for the profiling of lifestyle-associated changes in health

Mon, 01 Jan 2024 00:00:00 +0000

🔬 Research

Thu, 23 Nov 2023 00:00:00 +0000

Our overarching research interests are bioinformatics algorithms development for multi-omics and wearable data, and their application to precision medicine and biological questions.

💻 Method Development For Multi-Omics and Wearable Data

🧬 Mass Spectrometry Data

Mass spectrometry (MS) is an analytical technique used to measure the mass-to-charge ratio (m/z) of ions. It is a powerful tool for identifying the chemical structure of molecules in biological samples, including small molecules (metabolomics), proteins (proteomics), peptides (proteomics), and other biomolecules (lipidomics). We are working on the bioinformatics method and algorithm development (Deep Learning and Maching Learning) for Mass Spectrometry data processing and analysis, including whhole workflow of MS data, and metabolic network analysis. We are also working on the integration of MS data with other omics data, such as transcriptomics, proteomics and microbiome data (see below for more).

🦠 Microbiome Data

Research is defined as the creation of new knowledge and/or the use of existing knowledge in a new and creative way so as to generate new concepts, methodologies and understandings. This could include synthesis and analysis of previous research to the extent that it leads to new and creative outcomes.

⌚ Wearable Data

Multi-Omics and Wearable Data Integration

Precisione Medicine and Biological Questions

🧑 Aging

🤰 Pregnancy

Personal Health Monitoring and Disease Early Diagnosis

Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering

Thu, 26 Oct 2023 00:00:00 +0000

Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor

Mon, 20 Mar 2023 00:00:00 +0000

massDatabase utilities for the operation of the public compound and pathway database

Sat, 01 Oct 2022 00:00:00 +0000

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein

Mon, 19 Sep 2022 00:00:00 +0000

Deep learning-based pseudo-mass spectrometry imaging analysis for precision medicine

Wed, 10 Aug 2022 00:00:00 +0000

TidyMass an object-oriented reproducible analysis framework for LC–MS data

Thu, 28 Jul 2022 00:00:00 +0000

Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle

Fri, 01 Apr 2022 00:00:00 +0000

Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease

Fri, 25 Jun 2021 00:00:00 +0000

Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau

Mon, 06 Apr 2020 00:00:00 +0000

Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly

Tue, 24 Mar 2020 00:00:00 +0000

Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation

Fri, 20 Mar 2020 00:00:00 +0000

Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation

Mon, 04 Mar 2019 00:00:00 +0000

In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau

Tue, 01 Jan 2019 00:00:00 +0000

Mechanistic insights into the switch of αB-crystallin chaperone activity and self-multimerization

Sat, 01 Sep 2018 00:00:00 +0000

Versatile Structures of α-Synuclein

Mon, 20 Jun 2016 00:00:00 +0000

Photoluminescence Properties of La1/3NbO3: Sm3+ Coupled with Sr2+, Ba2+ and Bi3+ Under Near-UV Excitation

Tue, 01 Jan 2013 00:00:00 +0000